$0.00
BRAF 600V DNA, synthetic
$249.00
Description
The synthetic BRAF 600V DNA is a linear plasmid that contains a 773 bp DNA fragment of the human BRAF wild-type gene. The DNA insert covers the BRAF-600V (GTG) wild-type codon 600 and 5′- and 3′-flanking regions. The BRAF 600V (GTG) wild-type plasmid is verified by Sanger sequencing and linearized.
Mutant BRAF has been implicated in the pathogenesis of several cancers, including melanoma, non-small cell lung cancer, colorectal cancer, papillary thyroid cancer, and ovarian cancer. BRAF is altered in 6.01% of all cancers with colon adenocarcinoma, cutaneous melanoma, lung adenocarcinoma, melanoma, and thyroid gland papillary carcinoma having the greatest prevalence of alterations. In addition, BRAF is a predictive biomarker for use of drugs and antibodies in patients. Melanoma, colorectal carcinoma, non-small cell lung carcinoma, ganglioglioma, and gastrointestinal stromal tumor have the most therapies with BRAF as a predictive biomarker.
With synthetic BRAF 600V DNA you are able to
Analyze the sensitivity of BRAF PCR assay
Gain certainty of the limit of BRAF detection
Optimize and validate new cancer panels
Routinely monitor the performance of your BRAF assay
Product specification
| Name | BRAF 600V DNA, synthetic |
| Amount | 10 μL (1011 copies) |
| Length | 3775 bp |
| Molecular Weight | 2,332,437.88 Da |
| Form | 1010 copies/μL in Tris buffer, pH8.0 |
| Insert | BRAF 600V (GTG), 773 bp |
| Cloning vector | pGEM-T |
| Selection antibiotic | n/a |
| Sequencing primer | n/a |
| Application | In vitro research use only |
Delivery and storage
| Delivery | Cold packs |
| Storage | -20°C |
| Other Notes | Avoid freeze/thaw cycle. |
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