$0.00
BRAF V600K DNA, synthetic
$249.00
Description
The synthetic BRAF V600K DNA is a linear plasmid that contains a 773 bp DNA fragment of the human BRAF-V600K (AAG) gene. The DNA insert covers the BRAF-V600K (AAG) mutant codon and 5′- and 3′-flanking regions. The BRAF V600K (AAG) plasmid is verified by Sanger sequencing and linearized.
BRAF V600K is present in 0.16% of AACR GENIE cases, with melanoma, cutaneous melanoma, melanoma of unknown primary, esophageal melanoma, and lung adenocarcinoma having the greatest prevalence. Thus, BRAF V600K is a predictive biomarker for use of dabrafenib, vemurafenib, trametinib, binimetinib, cobimetinib, and encorafenib in patients.
With synthetic BRAF V600K Plasmid DNA you are able to
Analyze the sensitivity of BRAF PCR assay
Gain certainty of the limit of BRAF detection
Optimize and validate new cancer panels
Routinely monitor the performance of your BRAF assay
Product specification
| Name | BRAF V600K (AAG) DNA, synthetic |
| Amount | 10 μL (1011 copies) |
| Length | 3775 bp |
| Molecular Weight | 2,332,436.90 Da |
| Form | 1010 copies/μL in Tris buffer, pH8.0 |
| Insert | BRAF-V600K (AAG), 773 bp |
| Cloning vector | pGEM-T |
| Selection antibiotic | n/a |
| Sequencing primer | n/a |
| Application | In vitro research use only |
Delivery and storage
| Delivery | Cold packs |
| Storage | -20°C |
| Other Notes | Avoid freeze/thaw cycles. |
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