$0.00
BRAF V600R DNA, Synthetic
$249.00
Description
The synthetic BRAF V600R DNA is a linear plasmid that contains a 773 bp DNA fragment of the human BRAF-V600R (AGG) gene. The DNA insert covers the BRAF-V600R (AGG) mutant codon and 5′- and 3′-flanking regions. The BRAF V600R (AGG) plasmid is verified by Sanger sequencing and linearized.
BRAF V600R is present in 0.04% of AACR GENIE cases, with melanoma, cutaneous melanoma, melanoma of unknown primary, pancreatic adenocarcinoma, and duodenal adenocarcinoma having the greatest prevalence. In addition, BRAF V600R is a predictive biomarker for use of dabrafenib, vemurafenib, binimetinib, cobimetinib, encorafenib, and trametinib in patients. Of the therapies, melanoma has the most therapies targeted against BRAF V600R or its related pathways.
With BRAF V600R DNA you are able to
Analyze the sensitivity of BRAF PCR assay
Gain certainty of the limit of BRAF detection
Optimize and validate new cancer panels
Routinely monitor the performance of your BRAF assay
Product specification
| Name | BRAF V600R (AGG) DNA, synthetic |
| Amount | 10 μL (1011 copies) |
| Length | 3775 bp |
| Molecular Weight | 2,332,437.88 Da |
| Form | 1010 copies/μL in Tris buffer, pH8.0 |
| Insert | BRAF-V600R (AGG), 773 bp |
| Cloning vector | pGEM-T |
| Selection antibiotic | n/a |
| Sequencing primer | n/a |
| Application | In vitro research use only |
Delivery and storage
| Delivery | Cold packs |
| Storage | -20°C |
| Other Notes | Avoid freeze/thaw cycles. |
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