Custom Antibody-MMAE Conjugate(protein-MMAE)

Custom Antibody-MMAE Conjugate(protein-MMAE)

BC1004. In stock N/A .

Description

We offer antibody-MMAE conjugation service to create high-quality custom antibody-MMAE conjugates that are commonly used for cancer-targeted therapy. The antibody-MMAE conjugate selectively binds to the target cell and delivers the monomethyl auristatin E (MMAE) drug into it. Following internalization into the cell, the highly potent MMAE drug interacts with tubulins and inhibits the assembly of microtubules, killing itself at an extremely low concentration. Thus, the antibody-MMAF conjugate is very useful for the early-stage screening of antibodies.

Our antibody-MMAE conjugation service uses a cleavable linker (VC-PAB) to attach MMAE to primary amines on the antibody. We can also couple MMAE to non-antibody proteins or nucleic acids. The customer only needs to supply the desired antibody. Moreover, our custom antibody-MMAE conjugates are featured by high purity and activity.

Payload information

  • Name: Auristatin E (MMAE)
  • CAS number: 646502-53-6
  • Mechanism of action: binds to tubulin and blocks cell division by inhibiting the assembly of microtubules

custom antibody-MMAE conjugate

Advantages of custom antibody-MMAE conjugate 

  • Any antibody possible to label
  • Average 1-4 MMAE labeling per antibody
  • Proteinase cleavable
  • Yield up to 90%
  • Excess drug removal
  • High purity of the conjugate
  • Lead time 2-3 weeks

Submission of Antibody and Protein
We accept antibody samples that do not meet the below recommendations. However, the process may cause the loss of some materials.

  • Whole molecule or fragment (F(ab’)2, Fab, scFv, Fab’, VHH)
  • Highly purified
  • High concentrations
  • Free of carrier proteins (albumin, etc.)
  • No amine salts (Tris, etc.)
  • No free amino acids (glycine, etc.)

Please contact us to get a quote or email info@clickbios.com.