Custom Antibody-MMAF Conjugate (protein-MMAF)

Custom Antibody-MMAF Conjugate (protein-MMAF)

BC1005. In stock N/A .

Description

We offer antibody-MMAF conjugation services to create high-quality custom antibody-MMAF conjugates that are commonly used for cancer-targeted therapy. The conjugate selectively binds to the target cell and delivers the monomethyl auristatin F (MMAF) drug into it. Following internalization into the cell, the highly potent MMAF drug interacts with tubulins and inhibits the assembly of microtubules, killing itself at an extremely low concentration. We offer 2 types of custom antibody-MMAF conjugate, with or without a Val-Cit-PAB linker. Thus, the antibody-MMAF conjugate is very useful for the early-stage screening of antibodies. We can also couple MMAF to non-antibody proteins. Our custom antibody-MMAF conjugates are featured in high purity and activity.

Payload information

  • Name: Auristatin F (MMAF)
  • CAS number: 863971-19-1
  • Mechanism of action: binds to tubulin and blocks cell division by inhibiting the assembly of microtubules

custom antibody-MMAF conjugate

Advantages of our custom antibody-MMAF conjugate 

  • Any antibody or protein possible to label
  • Well-controlled drug-to-antibody ratio (3-4 MMAF labeling per antibody)
  • Options of proteinase cleavable and non-cleavable linker
  • Yield up to 90%
  • Removal of excess drug
  • High purity
  • Lead time 2-3 weeks

Submission of Antibody or Protein
We accept antibody samples that do not meet the below recommendations. However, the process may cause the loss of some materials.

  • Whole molecule or fragment (F(ab’)2, Fab, scFv, Fab’, VHH)
  • Highly purified
  • High concentrations
  • Free of carrier proteins (albumin, etc.)
  • No amine salts (Tris, etc.)
  • No free amino acids (glycine, etc.)

Please contact us to get a quote or email info@clickbios.com.