Description

The synthetic IDH1 R132 DNA is a linear plasmid that contains a 573 bp DNA fragment of the human IDH1 R132 (CGT) gene. The DNA insert covers the IDH1-R132 (CGT) wild-type codon and 5′- and 3′-flanking regions. The IDH1 R132 plasmid is verified by Sanger sequencing and linearized.

The IDH1 gene (isocitrate dehydrogenase 1 (NADP+), soluble) encodes for the isocitrate dehydrogenase [NADP] cytoplasmic protein, an epigenetic modifier. IDH1 is frequently mutated in glioma and acute myeloid leukemia, among other cancer types. IDH1 is altered in 2.85% of all cancers with anaplastic astrocytoma, oligodendroglioma, astrocytoma, conventional glioblastoma multiforme, and anaplastic oligodendroglioma having the greatest prevalence of alterations. The most common alterations in IDH1 are IDH1 Mutation at the position R132.

With synthetic IDH1-R132 DNA you are able to
Analyze the sensitivity of IDH1 PCR assay
Gain certainty of the limit of IDH1 detection
Optimize and validate new cancer panels
Routinely monitor the performance of your IDH1 assay

Product specification

Delivery and storage

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