$0.00
IDH1 R132H DNA, synthetic
$249.00
Description
The synthetic IDH1 R132H DNA is a linear plasmid that contains a 573 bp DNA fragment of the human IDH1 R132H (CAT) gene. The DNA insert covers the IDH1-R132H (CAT) mutant codon and 5′- and 3′-flanking regions. The IDH1 R132H plasmid is verified by Sanger sequencing and linearized.
The IDH1 gene (isocitrate dehydrogenase 1 (NADP+), soluble) encodes for the isocitrate dehydrogenase [NADP] cytoplasmic protein, an epigenetic modifier. IDH1 is frequently mutated in glioma and acute myeloid leukemia, among other cancer types. IDH1 R132H is present in 1.45% of AACR GENIE cases, with oligodendroglioma, anaplastic astrocytoma, astrocytoma, anaplastic oligodendroglioma, and conventional glioblastoma multiforme having the greatest prevalence. In addition, IDH1 R132H is a predictive biomarker for use of ivosidenib in patients. Acute myeloid leukemia, cholangiocarcinoma, and chondrosarcoma have the most therapies targeted against IDH1 R132H or its related pathways.
With synthetic IDH1-R132H DNA you are able to
Analyze the sensitivity of IDH1 PCR assay
Gain certainty of the limit of IDH1 detection
Optimize and validate new cancer panels
Routinely monitor the performance of your IDH1 assay
Product specification
| Name | IDH1-R132H (CAT) DNA, synthetic |
| Amount | 10 μL (1011 copies) |
| Length | 3574 bp |
| Molecular Weight | 2208327.65 Da |
| Form | 1010 copies/μL in Tris buffer, pH8.0 |
| Insert | IDH1-R132H (CAT), 573 bp |
| Cloning vector | pGEM-T |
| Selection antibiotic | n/a |
| Sequencing primer | n/a |
| Application | In vitro research use only |
Delivery and storage
| Delivery | Cold packs |
| Storage | -20°C |
| Other Notes | Avoid freeze/thaw cycles. |
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