Custom Oligonucleotide Conjugation

At Click Biosystems, we offer a custom oligonucleotide conjugation service. We are well-trained professionals in the conjugation of oligonucleotides (DNA and RNA). Our oligonucleotide conjugation technology is the most efficient and robust method in the field. The technology allows the conjugation of single- and double-stranded oligonucleotides to the molecule of your choice. In addition, we have developed the most user-friendly, high-efficiency oligonucleotide labeling kit for the conjugation of oligonucleotides to antibodies, enzymes, streptavidin, avidin, fluorescent proteins, dyes, and biotins. Thus, our customers can perform their own conjugations. Moreover, our well-established protocols allow us to provide reliable custom oligonucleotide conjugation services to meet your application needs. In fact, our custom oligonucleotide conjugation products are useful for assay developments, antibody productions, and therapeutic studies.

•Over 20 years of experience in handling protein and oligonucleotide bioconjugation;
•Select proper conjugation methods;
•Supply DNA and RNA oligos with proper modifications;
•Create and purify oligonucleotide conjugates;
•Determine the quality of oligonucleotide conjugates;
•High yield;
•High purity;
•Various QC methods;
•Micrograms to grams-scale conjugation;
•Validated oligonucleotide conjugation kit.

Service Areas
•Custom antibody-oligonucleotide conjugation, including intact antibody molecules and fragments;
•Site-specific streptavidin-oligonucleotide conjugation service;
•Conjugation of oligonucleotides to enzymes (HRP, alkaline phosphatase, glucose oxidase, invertase, and luciferase);
•Oligo-fluorescent protein conjugation services, such as oligo-phycoerythrin (PE), allophycocyanin (APC), and peridinin-chlorophyll-protein (PerCP) conjugation;
•Conjugation of the oligonucleotide to Keyhole limpet hemocyanin (KLH) or serum albumin (BSA, OVA);
•Labeling of oligos with a fluorescent dye (FITC, Rhodamine, Alexa Fluor, Cy dyes, etc.);
•Oligo-biotin conjugation service;
•Oligonucleotide-drug conjugation, such as maytansine (DM1), auristatin (MMAE), and paclitaxel;
•Peptide-oligonucleotide conjugation;
•Polymer-oligonucleotide conjugation (Pegylation, dendrimer, etc.)
•Immobilization of oligonucleotide to a solid support (gold nanoparticle, agarose, sepharose, and magnetic bead).

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