Custom Polymer Conjugation

At Click Biosystems, we provide custom polymer conjugation services. Polymers are extremely useful carriers for improving drug delivery and bioanalytical sensitivity. Polyethylene glycol (PEG), serum albumin (HSA), polyglutamic acid (PGA), N-hydroxymethyl methacrylamide copolymer (HPMA), poly(lactic-co-glycolic acid) (PLGA), Hyaluronic acid, and polyamidoamine (PAMAM) dendrimers are the most commonly used to create conjugates.

We will examine all the chemical and biological properties of the target molecule. We examine size, solubility, free drug as impurity, stability, hydrophilic/hydrophobic balance, poly-dispersity, drug loading, etc. In addition, the in vivo behavior, such as metabolism, distribution, pharmacokinetic, interaction with cells and blood components, specific targets will also be considered. Our well-established and optimal protocols allow us to provide reliable custom polymer conjugation services to meet your application needs. Our custom polymer conjugates are useful for assay developments, antibody productions, and therapeutic studies.

Advantages of polymer conjugates

•Increasing solubility and stability of hydrophobic drugs;
•Increasing cell penetration of large molecules, such as proteins and oligonucleotides;
•Delivering more drugs to the target tissue, such as tumors, resulting in enhanced therapeutic efficacy;
•Adding tumor targeting ligands, such as antibodies and peptides;
•Reducing undesirable side effects and reduced frequency of dosing;
•Improving bioanalytical sensitivity by loading more ligands, such as antibodies, enzymes, probes, peptides, and oligonucleotides.

Polymers for conjugation

•Polyethylene glycol (PEG)
•Human serum albumin (HSA)
•Polyglutamic acid (PGA)
•N-hydroxymethyl methacrylamide copolymer (HPMA)
•Poly(lactic-co-glycolic acid) (PLGA)
•Hyaluronic acid
•Polyamidoamine (PAMAM) dendrimers

Service areas

•Pegylation of proteins, peptides and oligonucleotides;
•Drug-polymer conjugation for drug delivery, including paclitaxel and doxorubicin;
•Antibody-polymer conjugation;
•Enzyme-polymer conjugation, including HRP, alkaline phosphatase, glucose oxidase, luciferase;
•Peptide-polymer conjugation;
•Dyes-polymer conjugation;
•Biotin-polymer conjugation;
•Oligonucleotide-polymer conjugation, including siRNA, ssDNA and dsDNA;
•Fluorescent protein-polymer conjugation, including green fluorescent protein (GFP, EGFP), red fluorescent protein (RFP), R-phycoerythrin (R-PE), B-phycoerythrin (B-PE), allophycocyanin (APC) and peridinin-chlorophyll-protein (PerCP).

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