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Bioconjugation is a complicated process to form a covalent link between two molecules, at least one of which is a biomolecule. With our advanced technologies, we offer a full spectrum of custom bioconjugation services. Our bioconjugation products are widely used in diagnostic assay, therapy, vaccination, and purification.
Why Choose Our Custom Bioconjugation Services
Although bioconjugation is a chemical process, it requires a deep understanding of biology and chemistry. Above all, a successful conjugate should maintain all the functions of its individual parts. Thus, a proper conjugation requires a sufficient knowledge of the reactive groups, reagent types, and functional groups on the molecules. It is also crucial to understand how modification of a molecule can potentially affect its activity. We have extensive knowledge about active sites and residue accessibility of biomolecules. In addition, our hands-on experience enables us to choose correct residues for conjugations, a proper solvent for modification and conjugation reaction, and a mild purification process.
Our General Approach to Bioconjugation
• Modification of both molecules by crosslinkers
• Removal of crosslinkers in excess
• Coupling of modified molecules
• Purification of bioconjugates
• Quality assurance
Custom Bioconjugation Services at Click Biosystems
We provide one-stop-shop custom bioconjugation services, including biomolecule preparation, modification, conjugation, and purification. We also have ability to analyze and test the conjugate. Hence, in a typical service, customers only need to specify molecules for conjugation. Then we will design a proper approach to creating the final product. Finally, we manufacture the conjugate for the customer.
Please click below links to discover more about our custom bioconjugation services.
• Peptide-carrier protein conjugation
• Protein/antibody conjugation
• Oligonucleotide bioconjugation
• Polymer conjugation
• Particle conjugation
• Pre-activation of biomolecules
Applications of Our Custom Bioconjugation Products
| Molecule-1 | Molecule-2 | Application |
| Carrier protein (KLH, Blue carrier, BSA, OVA, toxoid) | Peptide, compound, oligonucleotide, carbohydrate | Antibody production |
| Antibody | Drug, dye, enzyme, fluorescent protein, oligonucleotide | drug delivery, immunoassay |
| Streptavidin | Dye, enzyme, fluorescent protein, oligonucleotide | Immunoassay |
| Oligonucleotide | Dyes, enzyme, fluorescent protein | Diagnosis |
| Polymer (PEG, Dextran, Chitosan, dendrimer) | Drug, protein, oligonucleotide | Drug delivery |
| Bead or Resin (agarose, nanoparticle) | Protein, enzyme, compound oligonucleotide | Purification, diagnosis |
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