Description

The synthetic Ovalbumin mRNA (OVA mRNA) expresses the ovalbumin protein when transfected into mammalian cells. The codons of Ovalbumin mRNA are optimized for mammalian expression with the depletion of U bases. It has a cap-1 structure and a long polyA₁₂₀ tail. The unmodified, synthetic Ovalbumin mRNA activates the innate immune system and production of cytokines, which will influence the overall induced immune response. We also offer N¹-methylpseudouridine modified Ovalbumin mRNA that can reduce the innate immune response.

Ovalbumin is a chicken protein allergen mainly found in egg white. It is commonly used to sensitize immune reactions. As a heterologous gene, Ovalbumin mRNA may promote the growth and proliferation of immune cells, thereby enhancing the host’s anti-tumor and anti-viral ability. Expression of Ovalbumin mRNA in bone marrow-derived dendritic cells results in prominent OVA-specific cytotoxic T lymphocyte activity in vivo and antitumor effects. Moreover, nanoparticle encapsulated OVA mRNA reduced the tumor growth rate in lymphoma-bearing mouse models.

• Codon-optimized for expression in mammalian cells
• U-depletion
• 5′- m⁷G cap (Cap-1)
• Long polyA₁₂₀ tail

Product specification

Name	Ovalbumin mRNA, synthetic
Amount	50 μgs
Structure
Gel Mobility	Pass
Form	lyophilized powder from nuclease-free water
Application	In vitro research use only

Delivery and storage

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